dr james c wittig, orthopedic oncologist, new york, new jersey
Patient Education
Soft Tissue Tumor Classification
General Type Benign Entity Malignant Entity
Fibrous Producing Benign Fibrous Malignant Fibrous

(Fibrous Tissue Producing)

Calcifying Aponeurotic Fibroma
Dermatofibrosarcoma Protuberans (DFSP)
Desmoplastic Fibroblastoma (Collagenous Fibroma)
Elastofibroma
Fibromatosis

Fibroma of Tendon Sheath
Fibrous Hamartoma of Infancy
Infantile Digital Fibromatosis
(Inclusion Body Fibromatosis)
Myofibroma
Solitary Fibrous Tumor

Fibrosarcoma

  • Grade 1 (Low Grade)
  • Grade 2 (Intermediate)
  • Grade 3 (High Grade)

Malignant Fibrous Histiocytoma
(MFH) (aka: Myxoid Fibrosarcoma)
Low Grade Fibromyxoid Sarcoma
Infantile Fibrosarcoma
Myofibrosarcoma

Fat Producing Benign Fatty Malignant Fatty
  Lipoma
Angiolipoma
Hibernoma
Lipoblastoma
Liposarcoma (LS)
Well Differentiated LS
Myxoid Liposarcoma
Round Cell Liposarcoma
Pleomorphic Liposarcoma
Dedifferentiated LS
Muscle Origin Benign Muscle Malignant Muscle
  Leiomyoma
Rhabdomyoma
Leiomyosarcoma
Rhabdomyosarcoma
Vascular Origin Beningn Vascular Malignant Vascular
(Blood Vessel Origin) Hemangioma
Lymphangioma
Glomus Tumor
Kaposiform Hemangio-endothelioma
Hemangioendothelioma
Hemangiopericytoma
Angiosarcoma
Infantile Hemangiopericytoma
Osseous Producing Benign Osseous Malignant Osseous
(Bone Producing)
(Osteoid Producing)
Myositis Ossificans
Ossifying Fibromyxoid Tumor
Osteosarcoma (OS)
(Extraskeletal Osteosarcoma)
Cartilage Producing Benign Chondroid Malignant Chondroid
(Chondriod Producing) Extraskeletal Chondroma
Chondrosarcoma (Extraskeletal)
Myxoid Chondrosarcoma
Mesenchymal Chondrosarcoma
Small Round Blue Cell Benign Small Round Blue Cell Malignant Small Round Blue Cell
(These tumors do not produce matrix; Non Matrix Producing)   Ewing Sarcoma / PNET
(Extraskeletal Ewing Sarcoma)
Rhabdomyosarcoma
(specific varieties)
Desmoplastic Small Round Blue Cell Tumor
Lymphoma
Giant Cell Benign Giant Cell Malignant Giant Cell
(rare in soft tissues) Giant Cell Tumor (GCT)
Aneurysmal Bone Cyst (ABC)
Malignant Giant Cell Tumor
Neurogenic Benign Nervous Malignant Nervous
(Nerve origin; Very rare to occur in bone) Schwannoma (aka: Neurilemoma)
Ancient Schwannoma
Neurofibroma
Intraneural Ganglion Cyst
Intraneural Lipoma
Malignant Peripheral Nerve-
Sheath Tumor (MPNST)
(aka: Neurofibrosarcoma)
Synovial/Intraarticular
(Joint Related)
Benign Synovial Malignant Synovial
  Ganglion
Fibroma of Tendon Sheath
Giant Cell Tumor of Tendon-
Sheath (GCT of Tendon Sheath)
Pigmented Villonodular Synovitis
(PVNS)
Synovial Chondromatosis
Synovial Hemangioma
Synovial Lipoma
Synovial Fibroma
Malignant PVNS
Synovial Chondrosarcoma
Synovial Liposarcoma
Miscellaneous Origin/
Unknown Origin
Benign Malignant
  Granular Cell Tumor
Myxoma
Alveolar Soft Parts Sarcoma
Clear Cell Sarcoma (Melanoma of Soft Parts)
Desmoplastic Small Cell Tumor
Epithelioid Sarcoma
Inflammatory Myxohyaline- Tumor of Distal Extremities
Synovial Sarcoma

Pediatric Soft Tissue Tumors Benign Malignant
  Calcifying Aponeurotic Fibroma
Infantile Fibromatosis
Fibrous Hamartoma of Infancy
Infantile Digital Fibromatosis
(Inclusion Body Fibromatosis)
Myofibroma
(Pediatric Myofibromatosis)
Lipoblastoma
Hemangioma
Lymphangioma
Kaposiform Hemangioendothelioma

Infantile Fibrosarcoma
Rhabdomyosarcoma
Desmoplastic Small- Cell Tumor
Infantile Hemangiopericytoma
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